The Diagnostic Value of Soluble Urokinase Plasminogen Activator Receptor in Crimean-Congo Hemorrhagic Fever Disease in Emergency Department

Aim: The urokinase-type plasminogen activator (uPA) system consists of a protease, receptor (urokinase-type receptor, uPAR), and inhibitors that can be expressed on various cell types. Previous literature shows the amount soluble (suPAR) secreted from affected cells is higher in Crimean-Congo hemorrhagic fever (CCHF) patients than healthy controls. Thus, we aimed to investigate diagnostic value suPAR differential diagnosis CCHF emergency services. Material Methods: Individuals over 16 years old with preliminary disease were divided into two groups as real time-polymerase chain reaction (RT-PCR) and/or IgM positive (CCHF group) RT-PCR negative (control group). Results: Eighty included this study. Forty virus PCR identified group 40 control group. median age was 45 (range, 16-91) years, 49 (61.3%) male. Leukocyte, platelet, fibrinogen levels significantly lower, while creatinine kinase, aPTT, D-dimer There no statistically significant difference between for SuPAR (p=0.386). In addition, not diagnosed examined, brucellosis, influenza, pneumonia found most common. Conclusion: use biomarker differentiation similar findings services investigated have value.